Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a family of heparan sulfate proteoglycans, anchored to the cell surface via a covalent linkage to glycosylphosphatidylinositol.

Etymologies

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Examples

  • Campos-Xavier AB, Martinet D, Bateman J, Belluoccio D, Rowley L, et al. (2009) Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.

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  • Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, et al. (1996) Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.

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  • The GPC5 gene encodes glypican 5, a member of the heparan sulfate preoteoglycans (HSPGs) that are bound to the external surface of the plasma membrane by glycosyl-phosphatidylinositol (GPI) linkage

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  • Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, et al. (1998) GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome.

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  • There are six glypican family members in the Human Genome (GPC1 to GPC6).

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  • The GPC5 gene encodes glypican 5, one of the six members of the heparan sulfate proteoglycan (HSPG) family.

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  • GPC3 is a member of the glypican family of glycosylphosphatidylinositol-anchored cell-surface heparan sulfate proteoglycans.

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