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- n. Plural form of gonadotroph.
Sorry, no etymologies found.
Special cells inside the pituitary known as gonadotrophs produce hormones (specifically gonadotropin-releasing hormone and luteinizing hormone, or LH) that control ovulation and fertility.
The investigators focused on a class of pituitary cells called gonadotrophs, which secrete luteinizing hormone (LH), critical for ovulation and fertility.
Paik WY, Cesnjaj M, Balla T, Tomić M, et al. (1995) Effects of the phospholipase-C inhibitor, U73122, on signaling and secretion in pituitary gonadotrophs.
The researchers previously discovered that gonadotrophs harbor insulin receptors, but no one really knew what the effect of insulin on those receptors was.
To further clarify the effect of insulin on the pituitary, the researchers compared the gonadotrophs of obese mice to those of lean mice by injecting the animals with gonadotropin-releasing hormone (GnRH), which stimulates LH and is critical for ovulation and fertility.
The researchers suspected that when awash with too much circulating insulin, the gonadotrophs of obese mice start pumping out large amounts of LH, thus disrupting ovulation.