Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
haemocyte .
Etymologies
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Examples
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They utilise a couple of generalized blood cell types, called haemocytes, more on this later.
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In protovertebrates without a clotting system, wounds are plugged with haemocytes, primordial versions of the white blood cells and platelets that are activated by thrombin and trypsin.
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This would make a simple, if weak, clot that could stabilise the haemocytes.
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Also, while protovertebrates such as sea squirts have no true fibrinogen, their haemocytes are enriched with the protein cortical granule lectin 16.
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This form of factor XIII is also found sea squirts, invertebrate relatives of ours, in the cells that form haemocytes 13.
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Trypsin or trypsin-like enzymes, leaking from damaged cells attracting haemocytes to plug a wound, would be the start of a protoclotting system.
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A simple mutation to the small Factor XIII would allow it to crosslink one of the protofibrinogens, such as cortical granule lectin, that are present in, and released from, haemocytes.
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Sea squirts have a short Factor XIII protein 13, which can be activated and released from haemocytes via non-standard pathways.
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But a protothrombin that is activating a PAR receptor has a job to do: attracting haemocytes to a wound to plug it.
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Invertebrates such as lobsters and shrimp have a simple “one step” coagulation system, where a Factor XIII-like clotting factor is released by haemocytes and crosslinks a coagulation protein into a clot.
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