Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A coccidiostat used in veterinary medicine; a synthetic halogenated derivative of febrifugine.
Etymologies
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Examples
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Science, they show that a small-molecule compound known as halofuginone inhibits the development of Th17 cells, immune cells recently recognized as important players in autoimmune disease, without altering other kinds of T cells involved in normal immune function.
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Mice with a multiple sclerosis-like disease were far less severely affected when given low doses of the hydrangea-based drug, which is called halofuginone, the journal Science reported.
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Ms. Furlong, president of Parent Project Muscular Dystrophy, says the patient-advocacy group might be interested in financially supporting Halo's efforts with halofuginone.
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Medica Venture Partners, an Israel-based venture capital company that set up Collgard to develop halofuginone, raised $20 million from investors to work on the drug, says Yoav Waizer , Medica's chief financial officer.
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Medica was surprised by the offer from the families to buy halofuginone, says Eli Hazum , the company's general partner.
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And Collgard, which was exploring halofuginone for other diseases, had run trials in people that provided safety data on the drug.
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The Wicka and Seckler families hired Marc Blaustein , a former executive at biotechnology company Dyax Corp., to oversee the halofuginone program through a new company they named Halo Therapeutics.
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They injected mice for three to six days with halofuginone, which mimics the effects of being deprived of tryptophan, and found that it protected the kidneys as well.
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(In mice with another form of EAE that doesn't involve Th17 cells, halofuginone had no effect.)
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Th17 cells normally differentiate from "naïve" CD4+ T cells, but when Sundrud and colleagues cultured mouse CD4+ T-cells along with cytokines that normally induce Th17 development, there was a pronounced decrease in Th17 cells - but not in Th1, Th2 or T regulatory cells - when halofuginone was added.
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