haploidentical love


from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Having the same haplotype


Sorry, no etymologies found.


  • When a patient and donor are mismatched (known as haploidentical transplants), high doses of stem cells can overcome rejection, a principle that has been successfully pioneered in animal models by study co-author Yair Reisner, MD.


  • Ruggeri et al. demonstrated that NK cell alloreactivity can control relapse of acute myeloid leukemia (AML) without causing graft-versus-host disease (GVHD) in the setting of HLA-mismatched haploidentical allogeneic SCT

    PLoS ONE Alerts: New Articles

  • Meyer-Monard S, Passweg J, Siegler U, Kalberer C, Koehl U, et al. (2009) Clinical-grade purification of natural killer cells in haploidentical hematopoietic stem cell transplantation.

    PLoS ONE Alerts: New Articles

  • These ex vivo-generated NK cell products can be exploited for adoptive immunotherapy either following haploidentical SCT for boosting NK cell-mediated graft-versus-leukemia reactivity or in the non-transplant setting following lymphodepleting immunosuppressive regimens.

    PLoS ONE Alerts: New Articles

  • Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, et al. (2005) Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.

    PLoS ONE Alerts: New Articles

  • In addition, haploidentical NK cell infusions together with IL-2 in a non-transplantation setting have been associated with complete hematologic remission in poor-prognosis patients with AML

    PLoS ONE Alerts: New Articles

  • Esser R, Zimmermann S, Tonn T, Kotchetkov R, et al. (2005) Ex vivo expansion of highly purified NK cells for immunotherapy after haploidentical stem cell transplantation in children.

    PLoS ONE Alerts: New Articles

  • For the first time, high doses of T cells were administered in patients who underwent a haploidentical transplant (stem cells from a relative who is a partial match only), which included freshly purified T-regulatory cells to prevent graft-versus-host disease.

    EurekAlert! - Breaking News


Log in or sign up to get involved in the conversation. It's quick and easy.