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haploinsufficiency

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The state of a diploid organism having only a single copy of a particular gene, the other copy being inactivated due to mutation

Etymologies

Sorry, no etymologies found.

Examples

  • Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, et al. (1999) Genomic profiling of drug sensitivities via induced haploinsufficiency.

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  • If feedback regulation were predominant, transcription factor haploinsufficiency in humans would be less common.

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  • In the presence of strong compensatory mechanism that maintain protein levels, drug-induced haploinsufficiency would still be observed due to saturation of feedback mechanisms.

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  • Our data confirm that, although additive effects of haploinsufficiency at several genes may contribute to the full craniofacial or neurocognitive features of WBS, correct expression of GTF2I is one of the main players.

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  • Combined haploinsufficiency for both genes resulted in an even larger effect on apoptosis.

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  • Deutschbauer AM, Jaramillo DF, Proctor M, Kumm J, Hillenmeyer ME, et al. (2005) Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.

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  • Veitia RA (2002) Exploring the etiology of haploinsufficiency.

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  • Finally, haploinsufficiency as well as duplication sensitivity are likely to affect those master-regulators controlling the balanced expression of a range of other proteins

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  • These findings point towards a more complex relationship between haploinsufficiency and duplication sensitivity

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  • Magoh haploinsufficiency causes microcephaly because of INP depletion and neuronal apoptosis.

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