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Examples
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The players quickly converged on making a variant of a known structural feature called a helix-turn-helix.
Ars Technica John Timmer 2012
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Subsequent work has shown that homeodomain helix-turn-helix motifs are somewhat different from bacterial ones Branden, C., and Tooze, J.1999.
The Edge of Evolution Michael J. Behe 2007
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Subsequent work has shown that homeodomain helix-turn-helix motifs are somewhat different from bacterial ones Branden, C., and Tooze, J.1999.
The Edge of Evolution Michael J. Behe 2007
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Subsequent work has shown that homeodomain helix-turn-helix motifs are somewhat different from bacterial ones Branden, C., and Tooze, J.1999.
The Edge of Evolution Michael J. Behe 2007
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Subsequent work has shown that homeodomain helix-turn-helix motifs are somewhat different from bacterial ones Branden, C., and Tooze, J.1999.
The Edge of Evolution Michael J. Behe 2007
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The signal molecule binding region, which is located in the N-terminal portion of the protein and a helix-turn-helix motif (HTH) located in the C-terminal, which is responsible for the protein binding to the target promoters
PLoS ONE Alerts: New Articles Thomas Bjarnsholt et al. 2010
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The helix-turn-helix is a common motif and without a global sequence similarity, an evolutionary lineage based solely on active site similarity cannot be readily established.
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It also appears unlikely that PrgI and the Bcl-2 protein family would evolve through a convergent process since the helix-turn-helix is such a simple and ancient motif
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Evolving a readily available helix-turn-helix protein into either PrgI or the Bcl-2 protein family seems like a simpler path than the conversion of a uniquely distinct fold to incorporate a core helix-turn-helix motif.
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Importantly, the experimentally observed ligand-binding sites for both PrgI and Bcl-xL are functionally equivalent and within the conserved helix-turn-helix motif.
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