hemangioblasts

We are steadily moving toward the clinic with several cell therapy products that are manufactured from hemangioblasts.

Our preclinical research has also shown that hemangioblasts can repair vascular damage, including complications associated with diabetes, heart disease, and peripheral artery disease.

Importantly, hESC-derived hemangioblasts can provide an unlimited source of 'off-the-shelf' mesenchymal stem cells - which among their many potential applications − have been shown to repair damage after myocardial infarction, osteoarthritis, and to alleviate the debilitating symptoms of autoimmune diseases such as Crohn's irritable bowel syndrome and multiple sclerosis, among others.

Furthermore, we designed a novel cassette vector to simultaneously express an intronic mir-shRNA and a chimeric red fluorescent protein driven by lineage-specific promoter, which efficiently reduced the expression of a chromosomally integrated reporter gene and an endogenously expressed gata-1 gene in the developing erythroid progenitors and hemangioblasts, respectively.

Elites TV

The researchers achieved this by deriving hemangioblasts from embryonic stem cells (ESCs).

News-Letter

shows that hESC-derived hemangioblasts can differentiate into functional megakaryocytes and platelets on a large scale.