heparanase

Enzymatic activity responsible for the cleavage of heparan sulfate, commonly known as heparanase, is abundant in tumor-derived cells.

Naturejobs - All Jobs Rita Brun 2009

The team also discovered that autoimmune cells damage beta cells by producing heparanase, an enzyme which degrades heparan sulphate in beta cells.

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Posted on: Thursday, 18 February 2010, 08: 55 CST The enzyme heparanase plays a critical role in the spread of breast cancer cells to the brain, and, as such, is a promising target for

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These findings suggest that heparanase function is not limited to the process of tumor metastasis, but rather is engaged at the early stages of esophagus carcinoma initiation and progression.

Naturejobs - All Jobs Rita Brun 2009

Although heparanase upregulation and its pro-malignant features are well documented, the instance of its induction in the course of tumor development was less investigated.

Naturejobs - All Jobs Rita Brun 2009

Notably, heparanase induction correlated with increased cell proliferation index revealed by Ki-67 staining.

Naturejobs - All Jobs Rita Brun 2009

Here, we used immunohistochemical analysis to investigate heparanase expression in normal esophagus, Barrett's esophagus without dysplasia,

Naturejobs - All Jobs Rita Brun 2009

Traditionally, heparanase activity was correlated with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination as a consequence of heparan sulfate cleavage and remodeling of the extracellular matrix barrier.

Naturejobs - All Jobs Rita Brun 2009

Posted on: Wednesday, 25 November 2009, 14: 31 CST Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of

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