Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any enzyme that catalyses the hydrolysis of heparan sulfate into oligosaccharides

Etymologies

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Examples

  • Enzymatic activity responsible for the cleavage of heparan sulfate, commonly known as heparanase, is abundant in tumor-derived cells.

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  • The team also discovered that autoimmune cells damage beta cells by producing heparanase, an enzyme which degrades heparan sulphate in beta cells.

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  • Posted on: Thursday, 18 February 2010, 08: 55 CST The enzyme heparanase plays a critical role in the spread of breast cancer cells to the brain, and, as such, is a promising target for

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  • These findings suggest that heparanase function is not limited to the process of tumor metastasis, but rather is engaged at the early stages of esophagus carcinoma initiation and progression.

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  • Although heparanase upregulation and its pro-malignant features are well documented, the instance of its induction in the course of tumor development was less investigated.

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  • Notably, heparanase induction correlated with increased cell proliferation index revealed by Ki-67 staining.

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  • Here, we used immunohistochemical analysis to investigate heparanase expression in normal esophagus, Barrett's esophagus without dysplasia,

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  • Traditionally, heparanase activity was correlated with the metastatic potential of tumor-derived cells, attributed to enhanced cell dissemination as a consequence of heparan sulfate cleavage and remodeling of the extracellular matrix barrier.

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  • Posted on: Wednesday, 25 November 2009, 14: 31 CST Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of

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