from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. having seven helices; especially describing a portion of a protein having seven associated α-helices
The scientists were able to see previously unobserved changes in the structure of rhodopsin, which is a model for the ubiquitous G protein coupled receptors (GPCRs), heptahelical, transmembrane receptors found in eukaryotic cells.
However, in primary human CD19+ B cells, which express both receptors in circulation, co-internalization, a hall mark of heptahelical receptor dimers, was not observed, suggesting that heterodimerization in primary cells is of minor relevance The perinatal lethality of mice with a deletion of Cxcr7
Like the other decoy receptors for chemokines CXCR7 does not activate heterotrimeric G-proteins, a compulsory step for typical signal transduction of heptahelical receptors
CXCR7, a heptahelical receptor with strong phylogenetic similarity to GPCRs , was shown to bind CXCL12 and CXCL11 with high affinity, but fails to induce typical chemokine responses, such as cell migration and associated intracellular signal transduction