Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A folded protein domain that binds to DNA and has a function in transcription

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

homeo- +‎ domain

Examples

  • These are the Hox genes; they are recognizable by virtue of the presence of a 60 amino acid long DNA binding region called the homeodomain, by similarities in sequence, by their role as regulatory genes expressed early in development, by the restriction of their expression to bands of tissue, by their clustering in the genome to a single location, and by the remarkable collinearity of their organization on the chromosome to their pattern of expression: the order of the gene's position in the cluster is related to their region of expression along the length of the animal.

    The Panda's Thumb: December 2005 Archives

  • One possible candidate for such front-loaded ˜information 'would be the homeodomain proteins.

    2007 September - Telic Thoughts

  • Subsequent work has shown that homeodomain helix-turn-helix motifs are somewhat different from bacterial ones Branden, C., and Tooze, J.1999.

    The Edge of Evolution

  • Antennapedia homeodomain and its complex with the operator

    Kurt Wüthrich - Autobiography

  • We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module and have determined the structure of this domain in complex with an H3K36me3-derived peptide.

    Naturejobs - All Jobs

  • CLV3 dependent activation of the two receptor systems represses the expression of WUSCHEL (WUS), a homeodomain transcription factor that is normally produced from OC cells, and which is required for the maintenance of stem cells

    PLoS ONE Alerts: New Articles

  • Six3a belongs to the SIX family of homeodomain proteins and is expressed in the most anterior neural plate at the beginning of neurogenesis in various species.

    BioMed Central - Latest articles

  • Otsuga D, Alonso JM, Ecker JR, Drews GN, et al. (2005) Class III homeodomain-leucine zipper gene family members have overlapping, antagonistic, and distinct roles in Arabidopsis development.

    PLoS ONE Alerts: New Articles

  • Paired-like homeodomain 2 (Pitx2), first identified as the gene responsible for the Axenfeld-Rieger syndrome, encodes a protein factor that, controlling cell proliferation in a tissue-specific manner, has a crucial role in morphogenesis.

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  • Boucher CA, King SK, Carey N, Krahe R, Winchester CL, et al. (1995) A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG) n repeat.

    PLoS ONE Alerts: New Articles

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