from The Century Dictionary and Cyclopedia

  • Noting an acid, a colorless compound, found in small quantity in normal urine and in plant-roots.


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  • Alkaptonuria (also known as ochronosis) is a genetic disorder characterised by the accumulation of homogentisic acid deposits in connective tissue.

    BioMed Central - Latest articles

  • Pigmentation of the sclera and ear cartilage occurred only after the age of 30 years and is extremely variable in severity. 3 Tendon and ligament ruptures occur with minimal provocation, and kidney stones probably form because of the extremely high levels of urinary HGA excretion (renal clearance rates of 400 to 500 ml per minute). 4�Diagnosis depends on typical radiological findings and demonstration of reducing substance-homogentisic acid in the urine. 4 Several therapeutic approaches have been used in patients with alkaptonuria. 5 High-dose vitamin C decreases urinary benzoquinone acetic acid but has no effect on HGA excretion and no credible studies have shown that treatment with vitamin C is clinically effective. 6 The main therapeutic step is direct pharmacologic reduction of HGA production with nitisinone, a triketone herbicide that inhibits

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  • [6, 9] homogentisic acid [6] hydroxylysine-rich peptides

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