Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A trimer, especially a biologically active one, derived from three identical monomers

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

homo- +‎ trimer

Examples

  • Studies also suggest that HSF1 has intrinsic stress-sensing capacity, as both Drosophila and mammalian HSF1 can be converted from a monomer to a homotrimer in vitro in response to thermal or oxidative stress Previous reports demonstrate that the conversion of HSF1 to the high-affinity DNA binding homotrimer is not robust in neuronal cells

    PLoS Biology: New Articles

  • As such, protein chaperones are often referred to as heat shock proteins, or Hsps. Although the mechanisms for HSF1 activation are incompletely understood, a multistep process occurs in response to stress that involves the interconversion of an inactive cytoplasmic monomer to a homotrimer, nuclear accumulation, DNA binding to HSEs, hyperphosphorylation, and target gene.

    PLoS Biology: New Articles

Comments

Log in or sign up to get involved in the conversation. It's quick and easy.