Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
hydroxylase .
Etymologies
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Examples
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It is the chemical that gets into the body via smoke but then is converted by enzymes called aryl hydrocarbon hydroxylases into a more potent chemical that is the epoxide of BP.
The New Super-Nutrition Ph.D. Richard A. Passwater 1991
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It is the chemical that gets into the body via smoke but then is converted by enzymes called aryl hydrocarbon hydroxylases into a more potent chemical that is the epoxide of BP.
The New Super-Nutrition Ph.D. Richard A. Passwater 1991
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PC, Oh J, Kelly B, Krishnamachary B, et al. (2005) OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010
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HIF-1 activity depends on the inhibition of the post-transcriptional hydroxylation of the subunit α by prolyl hydroxylases
PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010
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In mammals, three types of HIF prolyl-hydroxylases that have been identified: PHD1 (prolyl-hydroxylase domain), PHD2 and PHD3.
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Deletion of the ODDD in the HIF-1α / Fluc fusion protein prevents hydroxylation by prolyl-hydroxylases and abrogates HIF-1α (ODDD) - pVHL interaction.
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During hypoxia, however, inactivation of the prolyl-hydroxylases occurs, resulting in the stabilisation of HIF-α on account proteasomal degradation of the subunit being inhibited.
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HIF-1α protein is constantly modified posttranslationally by prolyl hydroxylases at Pro402 and / or Pro564 within the oxygen-dependent degradation (ODD) domain which promotes binding with pVHL (von Hippel-Lindau protein) and subsequent targeting for rapid proteasomal degradation.
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In mammals, three types of HIF prolyl-hydroxylases that have been identified: PHD1 (prolyl-hydroxylase domain), PHD2 and PHD3.
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In mammals, three types of HIF prolyl-hydroxylases that have been identified: PHD1
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