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- verb Third-person singular simple present indicative form of
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Generally, HIF-1α is degraded in an oxygen-dependent manner through the activity of PHD2 enzyme, which hydroxylates HIF-1α on proline residues 402 and 564, and this hydroxylated form is bound by the E3 ubiquitin ligase
Reduction of FAD by NADPH is slower by 100fold, the mutant en - zyme reacts with oxygen to form 25% oxidized enzyme and 75% flavin hy - droperoxide, which successfully hydroxylates the substrate.
[Aspartame fails to lower brain tyrosine levels in the rat because the rat's liver hydroxylates dietary phenylalanine so rapidly that plasma tyrosine levels rise even more than those of plasma phenylalanine (13,14).
The length of the acetyl moi - ety is very important in substrate recognition ; hydroxylation of aromatic compounds ; dihydroxylated compounds are trans - formed, no reaction with phenylacetate, 4-chlorobenzoate or 2-hydroxy - phenylacetate hydroxylates phenol derivatives ; a vari - ety of aromatic compounds that contain a hydroxyl group in para-position can be hydroxylated. 4-hydroxyphenylacetate hydroxylase is an effector for C1 and substrate for C2 ; substrates become hydroxylated at a position ortho to the hydroxyl group,
(enzyme was re - named into 27-monooxygenase because it hydroxylates the methyl group in position 27 )  5b-cholestane-3a,7a,12a-triol hydroxylase cholestanetriol
The mutant also hydroxylates the product 3,4-dihydroxybenzoate to form gallic acid ;, mutant enzyme with a disrupted hydrogen-bonding network, substitution of 8-Cl-FAD in the mutant gives about 1. 5fold increase in hydroxylation rate compared to the wild-type enzyme ) [33, 35, 39] 6 Stability pH-Stability 5. 5-6.5
Arg42 is involved in binding of the 2'-phosphoadenosine moiety of NADPH ;, mutant enzyme Y385F hydroxylates 3,4-dihydroxybenzoate to form gallic acid ) [4, 12, 22, 27, 35] P?