hyperactivated love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. activated as a result of hyperactivation

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

hyper- +‎ activated

Examples

  • According to the researchers, when the cells in the body lose the ability to control mTOR activity, mTOR is considered "hyperactivated."

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  • Researchers in his laboratory made this key discovery through genetic tests that demonstrate that healthy genes in charge of protein production can become cancerous when mTOR is hyperactivated.

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  • Ruggero said that the "dismal" clinical results seen with first generation mTOR inhibitor drugs like rapamycin "stemmed in part from the inadequate limit on unhealthy protein synthesis that is caused by hyperactivated mTOR."

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  • The phosphoinositide3-kinase (PI3K)/Akt and downstream mammalian target of rapamycin complex 1 (mTORC1) signalling cascades promote normal growth and are frequently hyperactivated in tumour cells. mTORC1 is also regulated by local nutrients, particularly amino acids, but the mechanisms involved are poorly understood.

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  • For the current paper, he and colleagues focused on a small molecule called BCI, which hyperactivated FGF signaling.

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  • It has recently been found that this enzyme, particularly an isoform called p110alpha, is hyperactivated in many forms of cancer.

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  • This suggests either that capacitating incubations make sperm more vulnerable to a hypothetical deleterious action of HC-056456, or that CatSpers have additional roles in controlling the flagellar beat, specifically the beat frequency of hyperactivated sperm.

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  • Using mice whose sperm express a mutant PKA catalytic subunit that is sensitive to the unique cell-permeant inhibitor 1NM-PP1, we found that acute application of the 1NM-PP1 to hyperactivated sperm did not remove waveform asymmetry.

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  • Thus, to maintain hyperactivation, sperm require both open CatSper channels and available external Ca Fig. 5A we asked whether removal of HC-0546456 would allow previously-hyperactivated sperm to recover waveform asymmetry.

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  • Specifically, we show that acute blockade of CatSper channels with compound HC-056456 prevents the onset of hyperactivation during capacitating incubations, and that application of HC-056456 to already-hyperactivated sperm causes a rapid reversible removal of waveform asymmetry.

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