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from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An increased sensitivity to pain, which in one form is caused by damage to nociceptors in the body's soft tissues.

from The Century Dictionary and Cyclopedia

  • n. In pathology, an abnormally great sensitiveness to pain.


From hyper- + algesia (Wiktionary)


  • 2004 Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection.

    The Other Brain

  • PINSKY: Well, there's something called hyperalgesia that's been increasingly reported, which is that opiates and opiods actually intensify pain.

    CNN Transcript Jul 15, 2009

  • And opioids, by the way, cause what's called hyperalgesia, a worsening of chronic pain.

    Vh1 Blog

  • Under heavy use, painkillers are in fact the cause of pain, a condition known as hyperalgesia.

    Deepak Chopra: High on Fame: Michael Jackson and Enabling Doctors

  • "[T] he use of a standardized extract of Cannabis sativa ... evoked a total relief of thermal hyperalgesia, in an experimental model of neuropathic pain, ... ameliorating the effect of single cannabinoids," investigators reported.

    Paul Armentano: When It Comes To Medical Pot, Rats Are Smarter Than Our Politicians

  • There are many reasons for this including problems with tolerance, addiction and a newer discovery known as opioid-induced hyperalgesia OIH -- where opioid medications eventually cause some to get even more sensitive to pain.

    The Full Feed from

  • The other bad news was the time frame for hyperalgesia is anywhere between 6-18 months.

    News for WSAV

  • Kinins play an important role in regulation of pain and hyperalgesia after tissue injury and inflammation by activating two types of G-protein-coupled receptors, the kinin B1 and B2 receptors.

    BioMed Central - Latest articles

  • Secondary hyperalgesia is pain sensitivity that occurs in surrounding undamaged tissue.


  • Increasingly often, individuals facing hyperalgesia, or sensitivity to pain, turn to diet and diet supplements for pain control and therapy.



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