from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective pathology Relating to, or caused by an
excessof androgenic hormones
from Wiktionary, Creative Commons Attribution/Share-Alike License
Exclude Non-classical 17-hydroxylase deficiency can look like PCOS HAIRAN - hyperandrogenic insulin resistance and acanthosis nigricans Adrenal tumor Cushing's Prolactin Thyroid Pituitary insufficiency Hypothalamic amenorrhea
However, much of the data regarding hyperandrogenic insulin resistance in humans has been observational Studies of the mechanism of insulin resistance of PCOS have found evidence of altered serine phosphorylation in the insulin receptors of cultured skin fibroblasts from PCOS patients, which inhibited IR activation by tyrosine autophosphorylation in response to insulin stimulation
High-dose testosterone pre-exposure attenuated the insulin-induced mTOR-Ser The data demonstrated an interaction between testosterone and insulin on phosphorylation of intracellular signaling proteins, and suggests a link between a hyperandrogenic, hyperinsulinemic environment and the development of insulin resistance involving serine phosphorylation of IRS-1 Ser
The phosphorylated signal of S6K Thr The current study reports a link between a hyperinsulinemic / hyperandrogenic environment and an elevation in serine phosphorylation of IRS-1, which has been associated with insulin resistance.
PCOS is characterized by a hyperandrogenic state and exposure to exogenous testosterone (T) in vivo has been associated with insulin resistance in rats and human females