from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Hypertrophy of the cornea or the horny layer of the skin.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Excess keratin formation on the skin surface, as can be seen in a number of dermatologic conditions.
from The Century Dictionary and Cyclopedia
- n. Hypertrophy of the horny layer of the epidermis.
- n. Same as conical cornea.
A clear indication of low vitamin A and omega-3 fat deficiency were “bumps” on the back of his arms called hyperkeratosis pilaris.6 His low level of vitamin D led to lowered immunity.7 Deficiencies of other vitamins such as vitamin E and beta carotene indicated he ate a diet high in junk food and low in vegetables and whole grains.
Skin roughening ( "hyperkeratosis") and concomitant hair loss was maximal in regions subjected to mechanical friction, such as abdomen fig. 3c), changes on the dorsal skin were mostly limited to scaling (fig. S2).
A callus is a form of hyperkeratosis, or thickened skin, that creates a hard surface.
The skin over the feet may show marked hyperkeratosis.
Pathologically the first change noted in the epidermis is thought to be an acanthosis, followed by epithelial atrophy, and a hyperkeratosis, intercellular edema, and colloid degeneration of the prickle cells.
H/E and Toluidin blue staining shows acanthosis, hyperkeratosis, spongiosis, epidermoid cysts and massive infiltration of mast cells in the dermis of the N1N2K5 derived graft.
Moreover, both loss and gain of Notch function cause hyperkeratosis as a consequence of hair cycle disturbance
Both N1N2K5 and K14-TSLP mice show acanthosis, hyperkeratosis as well as dermal infiltration by mast cells [Scale bars: 50 µm].
We demonstrate that skin-specific inactivation of Notch1 and Notch2 simultaneously, or RBP-J, induces the development of a severe form of atopic dermatitis (AD), characterized by acanthosis, spongiosis and hyperkeratosis, as well as a massive dermal infiltration of eosinophils and mast cells.
Asterisks indicate enlarged regions of the skin showing acanthosis, hyperkeratosis and spongiosis of the epidermis as well as eosinophil infiltrates (arrows) around dilated blood vessels (bv) in the dermis (n = 8, 4 individual experiments were performed).