hypermethylated love



from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. methylated to an abnormally high degree


Sorry, no etymologies found.


  • Significantly, they are often found de-methylated in normal cells, but hypermethylated in cancer cells

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  • In the primary tumours, island 2 was hypermethylated in 14. 5% of the samples and island 4 was hypermethylated in 54% of the samples.

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  • The ESR1 promoter was hypermethylated in 41% of breast tumour samples.

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  • Subsequent to Sm core assembly, the snRNA cap is hypermethylated by the TGS1 methyltransferase to form 2,2,7-trimethylguanosine

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  • (H3K4me3), are present in all the unmethylated promoters analysed, and both of them are lost when these promoters become hypermethylated.

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  • We observed colocalization of hypomethylated R-DMRs with hypermethylated C-DMRs and bivalent chromatin marks, and colocalization of hypermethylated R-DMRs with hypomethylated C-DMRs and the absence of bivalent marks, suggesting two mechanisms for epigenetic reprogramming in iPS cells and cancer.

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  • Lin X, Nelson WG (2003) Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells.

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  • ↵ † We found that, in MET-treated mice (5.2 mmol / kg twice a day for 7 days), ≈ 5\% of the total gene promoters are hypermethylated when measured by DNA methylation microarrays (NimbleGen, 5mC - ChIP-chip) (unpublished data).

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  • 5-Aza-2-deoxycytidine treatment is thought to lead to the reactivation of aberrantly hypermethylated genes

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