hypermutations love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of hypermutation.

Etymologies

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Examples

  • Moreover hypermutations generated by this enzyme in oncogenes can cause malignancies in haematopoietic cells

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  • Importantly, we have also detected hypermutations in other exons of

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  • It is reasonable to suggest that other (s) yet unknown DNA polymerase (s) may be responsible for the high mutability rates we report here and more than one polymerase contributes to hypermutations Our results also argue that mutations are not completely random.

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  • POLH is expressed in all tissues and, in principle, could cause hypermutations in non-haematopoietic cells.

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  • It has been recently shown that the activation-induced cytidine deaminase (AID) is responsible for somatic hypermutations in activated B cells.

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  • Somatic hypermutations in tumor suppressor genes involved in major human malignancies offer a novel insight in cancer development, progression and spread.

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  • Analysis of microdissected H/RS-like cells revealed their origin as germinal center B cells bearing somatic hypermutations and, in some instances, crippled mutations, as described for human Hodgkin lymphoma (HL).

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  • The presence of mutations in FR1-FR3 and CDR1-CDR2, in addition to mutations in the CDR3-regions of VDJ-junctions, would indicate that tumor cells originated from mature, activated B cells of germinal centers with ongoing somatic hypermutations (SHM).

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