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  • noun genetics Any agent that causes hypermutation


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  • Thus, patients who initially respond to temozolomide may evolve not only treatment resistance but also a hypermutator phenotype (since DNA repair genes have been mutated).

    The Highlight HEALTH Network 2008

  • By integrating methylation data, somatic mutation data and clinical treatment data, scientists identified a relationship between MGMT methylation and a hypermutator phenotype described previously [6].

    The Highlight HEALTH Network 2008


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