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hyperosmolarity

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An abnormally high osmolarity

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

hyper- +‎ osmolarity

Examples

  • Real time PCR analysis of SPAK mRNA expression in mucosa from colon tissue of hyperosmolarity treated mice. ** p doi: 10.1371 / journal. pone.0005049.g002

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  • In addition, hyperosmolarity treatment (in the absence of AcD treatment) markedly increased levels of SPAK mRNA transcripts.

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  • Furthermore, hyperosmolarity leads to redistribution and polymerization of cortical F-actin, which is involved in the downregulation of cellular permeability

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  • We used the SPAK TATA-less promoter to study the mechanisms underlying the hyperosmolarity-induced changes in SPAK expression during intestinal inflammation.

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  • These in vivo data show that hyperosmolarity does not affect the overall nuclear levels of Sp1; however, hyperosmolarity treatment induces translocation of NF-κB (p65) to the nucleus and upregulates its expression level.

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  • We found that hyperosmolarity does not affect the overall nuclear levels of Sp1 in mice or Caco2-BBE cells, in agreement with previous results

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  • Expression of SPAK is enhanced in colon tissue from hyperosmolarity treated mice

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  • We found that Sp1 binding sites are important both for basal and hyperosmolarity-induced promoter activities, whereas the NF-κB binding site plays an important role in the hyperosmolarity-induced promoter activity.

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  • Briefly; nuclei were isolated from Caco2-BBE cells treated with or without hyperosmolarity for 1 hour.

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  • Immunostaining of SPAK in colonic Caco2-BBE cells treated with hyperosmolarity at 0 and 15 min.

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