hyperphosphatemia love



from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An elevated amount of phosphate in the blood


from Wiktionary, Creative Commons Attribution/Share-Alike License

From hyper- +‎ phosphatemia


  • Genzyme just launched Renvela in the U.S. in March, and said the company is in active discussions with the Food and Drug Administration to expand the product's labeling to include chronic kidney disease patients with hyperphosphatemia who are not on dialysis.

    Genzyme's Net Falls,

  • The market for phosphate binders to treat hyperphosphatemia in ESRD patients in 2010 was approximately

  • Zerenex has the potential to be an effective and safe treatment in lowering and/or maintaining normal serum phosphorus levels in patients with ESRD and hyperphosphatemia.

  • The Phase 3 clinical program of Zerenex in the treatment for hyperphosphatemia elevated phosphate levels in patients with end-stage renal disease is being conducted pursuant to an SPA agreement with the FDA.

  • NEW YORK, Sept. 19, 2011 /PRNewswire/ -- Keryx Biopharmaceuticals (Nasdaq: KERX - News) today announced completion of patient enrollment in the long-term study component of its Phase 3 registration program of Zerenex™, the Company's ferric iron-based phosphate binder for the treatment of elevated serum phosphorus levels, or hyperphosphatemia, in patients with end-stage renal disease (ESRD) on dialysis.

  • Phosphate retention and the resulting hyperphosphatemia in patients with ESRD on dialysis are usually associated with secondary hyperparathyroidism, renal osteodystrophy, soft tissue mineralization and the progression of renal failure.

  • Dietary restriction of phosphate has long been the cornerstone of therapy, but this measure is usually not sufficient to control hyperphosphatemia.

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  • Keryx also has an SPA for Zerenex, its hyperphosphatemia drug, which will start Phase III soon.

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  • The identification of genetic alterations in Mendelian disorders of hypophosphatemia and hyperphosphatemia has led to the isolation of novel genes and the identification of new roles for existing proteins-such as fibroblast growth factor 23 and its processing systems, the co-receptor α-klotho, and phosphate transporters-in the control of renal phosphate handling.

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  • Long-term data to be presented suggest that use of Zerenex may also potentially reduce the need for intravenous iron and erythropoietin in hyperphosphatemia patients on dialysis

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