hyperproliferative love



from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective Of, pertaining to, or causing hyperproliferation


Sorry, no etymologies found.


  • Loss of Notch signaling in N1N2K5 or RBP-JK5 mice leads to an even more hyperproliferative phenotype with Ki67 positive cells throughout the entire epidermis, which is also K14 positive.

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  • Hence, sAC may play a role in the pathogenesis of certain hyperproliferative skin disorders via modulation of gene expression.

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  • As Notch has been shown to induce early differentiation events and has been linked to cell cycle withdrawal, it is possible that diminished Notch receptor expression is common to many hyperproliferative skin disorders rather then specific to AD.

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  • Koegel H, von Tobel L, Schafer M, Alberti S, Kremmer E, et al. (2009) Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice.

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  • However, in certain hyperproliferative disorders of the skin, including psoriasis, verruca vulgaris, and SCCIS on sun-damaged skin, sAC keratinocyte staining was predominantly nuclear.

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  • Mice lacking Notch2 in the epidermis are indistinguishable from controls, whereas Notch1 deficient mice show K14 expression throughout the epidermis (whereas it is confined to the basal layer in controls), have a hyperproliferative epidermis and a mild increase in toluidine blue positive mast cells.

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  • In contrast, in other hyperproliferative disorders, such as basal cell carcinoma, sAC staining was similar to normal human skin.

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  • ARF up-regulation in response to oncogenic hyperproliferative signals expression of p19ARF was not restricted to the Bmi1 − / − background but could also be observed to a lesser extent in BXB11 adenomas.

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  • The hyperkeratosis that results in horn formation develops over the surface of a hyperproliferative lesion.

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  • Cascade ProDrug Inc. is a new drug discovery company developing targeted therapeutics against hyperproliferative diseases.

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