from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Either of the peptide hormones orexin


Sorry, no etymologies found.


  • The gene turned out to be a receptor for a neurotransmitter called hypocretin or orexin (it has two different names because it was discovered at two different research labs the same year and named independently by both).

    In Search Of Sleep

  • What we know so far is that a previously unknown neurotransmitter a chemical that nerve cells release to stimulate other nerve cells called hypocretin or orexin has been found in the lateral hypothalamus, a region of the brain known to be important in the control of certain basic body functions such as appetite.

    Solve Your Child’s Sleep Problems

  • There is also some evidence that a brain chemical called hypocretin plays a role in narcolepsy.

    Medlogs - Recent stories

  • The mutant fish lacked a working receptor for hypocretin, a neuropeptide that is secreted in normal fish by neurons in the region of the brain that controls hunger, sex and other basic behaviours.

    Fish Suffer From Insomnia, Scientists Reported on Monday. | Impact Lab

  • Lower glucose levels in the brain may also lead to a stronger stress-catecholamine response, changes in hypocretin, similar to being on stimulants.

    Last gasp of the dark ages of nutrition | The Blog of Michael R. Eades, M.D.

  • That meshes with Saper's sleep-switch model: he proposes that hypocretin is the chemical in the hypothalamus most likely responsible for pushing the switch in the direction of wakefulness.

    In Search Of Sleep

  • Several weeks after Mignot's team published its finding, another team at the University of Texas Southwestern Medical Center at Dallas published a study showing that if hypocretin is knocked out of mice, the result is also a condition that resembles narcolepsy.

    In Search Of Sleep

  • The receptor has a mutation in narcoleptic dogs, leaving hypocretin with nothing to bind to.

    In Search Of Sleep

  • In 2000, they published another study showing that in seven of nine patients with narcolepsy, hypocretin levels were too low to detect.

    In Search Of Sleep

  • When glucose is elevated, hypocretin tells your brain to turn off the lights.

    Gary Taubes responds | The Blog of Michael R. Eades, M.D.


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