from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. An abnormally low level of insulin in the blood
When chronic, food restriction will also increase dopamine d2 receptor density, in addition to acutely producing a stimulant-like high from acute hypoinsulinemia and low IGF levels.
During early life the β-cell mass of these mice was increased; however, at older age they developed progressive hyperglycemia and hypoinsulinemia accompanied by a reduction in β-cell mass.
Perk KO mice was due to hypoinsulinemia associated with low insulin-secreting beta-cell mass caused by diminished beta-cell proliferation and impaired insulin secretion
Perk-deficient mice was largely impaired, beta-cell mass was increased sufficiently by T-antigen induction to rescue the hypoinsulinemia and diabetes in these mice.