Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective genetics, of a mutation causing a partial loss of gene function.

Etymologies

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Examples

  • Pten hypomorphic and a wild-type (wt) allele; hy/−, mice having a

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  • Pten hypomorphic and null allele; +/−, mice having a Pten wt and null allele.

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  • However, it did cause the formation of hypomorphic limbs as a result of increased cellular condensation and apoptosis.

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  • Pten hypomorphic and null allele; +/−, mice having a Pten wt and null allele.

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  • The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9.

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  • The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9.

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  • However, it did cause the formation of hypomorphic limbs as a result of increased cellular condensation and apoptosis.

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  • Taken together, these two latter findings have challenged the concept that Wnt signalling in osteoblasts is a key pathway for the regulation of bone formation, which was further underscored by the finding that the osteopenia of rs/rs mice, carrying a hypomorphic mutation of the Wnt co-receptor Lrp6, is caused by increased bone resorption

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  • However, it did cause the formation of hypomorphic limbs as a result of increased cellular condensation and apoptosis.

    BioMed Central - Latest articles

  • The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs (during development and regeneration) but did not affect the expression of BMP-2 and SOX-9.

    BioMed Central - Latest articles

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