from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective biochemistry
phosphorylatedto a less than normal extent, or less than fully
from Wiktionary, Creative Commons Attribution/Share-Alike License
This hypophosphorylated form of Rb is now capable of binding to E2F family members, resulting in suppression of their transcriptional transactivation potential during early G
Concurrent with this timeframe, the Rb protein is hypophosphorylated and MCMs have not loaded onto chromatin at the preRCs.
Moreover, the ZAK-RhoGDIbetainteraction may maintain ZAK in an inactive hypophosphorylated form.
KaiC, a central clock protein in cyanobacteria, undergoes circadian oscillations between hypophosphorylated and hyperphosphorylated forms in vivo and in vitro.
Accordingly, connection between the ubiquitin ligase MID1 / α4 and microtubule-associated PP2Ac is disrupted, the enzyme accumulates and microtubule-associated proteins are hypophosphorylated
Overexpression of cyclin D1 and cdk4 also affects later events in the FGF response The maintenance of FGF-induced growth arrest is characterized by the accumulation of hypophosphorylated p130 by 10-16 hrs of FGF treatment, that follows a dramatic drop in cyclin E / cdk2 activity between 6 and 12 hrs