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- noun biochemistry
phosphorylationto a less than normal extent, or less than fully
from Wiktionary, Creative Commons Attribution/Share-Alike License
HIF-1α-deficient cells, we observed changes in downstream effectors that are linked to the irreversible cell cycle arrest characteristic of senescence, e.g. p21 stabilization and hypophosphorylation of pRb.
Also, HIF-1α stabilized p21 and p27 as well as led to hypophosphorylation of pRb during hypoxia-induced growth arrest of immortalized murine embryonic fibroblasts and primary splenic B-lymphocytes
Indeed, both pRb hypophosphorylation and reduced cyclin A levels were confirmed in 5-FU-treated AGS KD cells and - to a lesser extent - also in AGS SCR cells (