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- adjective Alternative spelling of
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- adjective of or relating to the hypophysis
from Wiktionary, Creative Commons Attribution/Share-Alike License
Once in the pituitary, they determine the exact quantities of the various hypophyseal hormones which must be produced at a given point in time.
At this stage even if the hypophyseal treatment is discontinued the animals remain permanently diabetic, degeneration of the beta cells continues and the pancreas ceases to secrete insulin.
They are not due exclusively to hyperglycemia as proved by the fact that the same levels of blood sugar have been maintained during four days by continuous injection of glucose and by hypophyseal extracts injections.
Thus as the mass of the pancreas is progressively reduced by extirpation of increasingly larger portions, the dose of hypophyseal extract needed to provoke diabetes diminishes.
Extrapancreatic: factors are demonstrated by: (1) the diabetogenic effect obtained in pancreatectomized hypophysectomized animals; (2) the increase in the severity of diabetes in pancreatectomized dogs treated with anterohypophyseal extract; (3) the increase in resistance to insulin which precedes and accompanies hypophyseal diabetes; (4) the fact that hyperglycemia and diabetes occur before that there are visible lesions in the beta cells of the islets, and before insulin secretion diminishes.
It is possible that in acromegaly, in some stages of the disease there may be a hypophyseal diabetes and at others a metahypophyseal diabetes.
The diabetic conditions which persists when the hypophyseal treatment is discontinued, should be called metahypophyseal diabetes.
Hepatectomy causes a rapid fall in the blood sugar of dogs or toads with a hypophyseal diabetes.
A normal pancreas reestablishes the normal blood sugar level in three to five hours and maintains it there, while the pancreas taken from an animal in hypophyseal diabetes has little or no effect on the blood sugar.
The injection or implantation of anterior hypophyseal lobe reestablished or even increased the usual severity of diabetes.
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