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Examples
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Australian researchers tested icilin, a potent cooling agent in peppermint, on a sensory pathway called transient receptor potential ion channel melastatin subtype 8 TRPM8, found in the colon and other parts of the body.
Finding the Pathways to a Cause of Tinnitus Ann Lukits 2011
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Researchers believe TRPM8 provides a channel that allows icilin to reduce colonic inflammation.
Finding the Pathways to a Cause of Tinnitus Ann Lukits 2011
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Both compounds use different mechanisms of current activation; amino acid residues within the S2-S3 linker have been identified critical for current activation by icilin but not by menthol.
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We studied wild-type TRPM8 as well as an s3-TRPM8 mutant with mutations in the S2-S3 linker region that could not be activated by icilin.
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TRPM8 is a cation channel activated by cold temperatures and the chemical stimuli menthol and icilin.
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Finally, icilin suppressed current activation by the other agonists.
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Carboxyamide derivatives chemically resembling menthol have been described as activators of TRPM8 analogous to icilin.
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TRPA1 that is also stimulated by both menthol and icilin.
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None of the inhibiting effects of icilin occurred in the cation channel
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Thus, icilin specifically inhibits TRPM8 independently of its interaction site within the S2-S3 linker through a process distinct from
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