Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun immunology An
antibody that has a second material as aconjugate
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Wii-volution 2010
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The immunoconjugate was found to be stable with respect to loss of the radiolabel in vitro and immunoreactivity assays demonstrated that conjugation, radiolabeling and purification chemistries do not compromise the binding affinity or specificity for the HER2/neu antigen.
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Wii-volution 2010
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The immunoconjugate was found to be stable with respect to loss of the radiolabel in vitro and immunoreactivity assays demonstrated that conjugation, radiolabeling and purification chemistries do not compromise the binding affinity or specificity for the HER2/neu antigen.
PLoS ONE Alerts: New Articles Jason P. Holland et al. 2010
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Employing a proprietary chemical library platform, Onconova has discovered non-ATP competitive kinase inhibitors directed at validated and novel targets, and is developing a new immunoconjugate technology (comprising potent active compounds and proprietary linkers) that arm monoclonal antibodies for cancer therapy.
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The immunoconjugate contains an anti-EphA2 monoclonal antibody linked to the chemotherapy drug monomethyl auristatin phenylalanine (MMAF) through the non-cleavable linker maleimidocaproyl.
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In another colon cancer model, MST for the immunoconjugate treatment group increased 4-fold to 86 days compared to untreated animals, and was significantly better than all controls, including irinotecan administered at its maximum tolerated dose, which is a 50-fold increase in the amount of free drug than SN-38 in the immunoconjugate dose.
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Sood said that the immunoconjugate was highly specific in delivering MMAF to the tumour cells that expressed EphA2 while showing minimal uptake in cells that did not express the protein.
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"More preclinical evidences are being collected to support the human testing of this new drug immunoconjugate," she added.
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Employing a proprietary chemical library platform, Onconova has discovered non-ATP competitive kinase inhibitors directed at validated and novel targets, and is developing a new immunoconjugate technology (comprising potent active compounds and proprietary linkers) that arm monoclonal antibodies for cancer therapy.
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