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- n. The dominance of an antigen (over all others) in its ability to produce an immune response
Antigenic oscillations and shifting immunodominance in HIV-1 infections.
In order to define the target antigens and the relative immunodominance of the overall HIV-1-specific CD4 T cell response in clade C virus infection, we used an IFN-γ Elispot assay to screen for HIV-1-specific CD4+ responses using an overlapping peptide set spanning the entire HIV-1 clade C proteome in 32 randomly selected subjects.
These data demonstrate an immunodominance of Gag-specific CD4+ T cell responses related to control of viremia in clade C virus infection.
Kaufmann DE, Bailey PM, Sidney J, Wagner B, Norris PJ, et al. (2004) Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Sera from human patients with histoplasmosis were also used to assess the immunodominance of the three fragments, revealing that F2 was the most immunogenic region due to the presence of higher titers of antibodies from different classes of Igs against this fragment.