from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Any of a class of isomerases active in the immune system
Sorry, no etymologies found.
Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, et al. (1998) AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region.
For the first time, free energies of protein unfolding were determined by the innovative method and used to determine the affinity of a drug - the immunosuppressant rapamycin - to a protein, the cellular immunophilin FKBP12.
"CsA and FK506 each form complexes with a specific immunophilin binding proteins and it is these complexes, called IS-IP complexes, that inhibit CN activity," says senior study author Dr. Juan Miguel Redondo from the Department of Vascular Biology and Inflammation at the Centro Nacional de Investigaciones Cardiovasculares in Madrid.