from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The site on an antibody at which an antigen is bound
Sorry, no etymologies found.
Prior to this study, researchers knew that so-called immunoreceptor tyrosine-based activation motif (ITAM) - coupled receptors were involved in regulating inflammation, but they did not know how the ITAM pathways actually turned off inflammatory signaling.
Initially, the researchers found that the Mincle receptor is associated with another signaling receptor chain, FcRã and triggers macrophage activation through a specific sequence known as the immunoreceptor tyrosine-based activation motif (ITAM).
The St. Jude investigators sought to understand why T cell receptors need many copies of switch-like components called immunoreceptor tyrosine-based activation motifs (ITAMS).
HLA-E results in NK cells inhibition through the phosphorylation of the two immunoreceptor
Kitzig F, Sayos J, Lopez-Botet M (2002) Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor.
In most analysed species, ITAM (immunoreceptor tyrosine-based activation motifs) or ITAM-like motif-containing proteins exist which contain Ig-V-like, ligand binding domains closely related to that of CEACAM1.