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IMO-2125 has been shown to mediate immune responses through TLR9 and associated interferon-signaling pathways involving MyD88 and interferon-regulatory factor 7 (IRF-7) as evaluated in gene microarray studies.
In pDC the adaptor molecule MyD88 binds interferon-regulatory factor-7 (IRF-7) directly, which results in high type I IFN production following TLR9 ligation, whereas ligation of TLR9 in macrophages, B cells and murine myeloid dendritic cells (mDC) leads to activation of NF-κB