from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Capable of being ionized
from The Century Dictionary and Cyclopedia
- Capable of being ionized: used both of electrolytes and of gases.
Sorry, no etymologies found.
Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-dimethylaminopropane (DLinDMA), a key lipid component of stable nucleic acid lipid particles (SNALP) as a benchmark, we used the proposed in vivo mechanism of action of ionizable cationic lipids to guide the design of DLinDMA-based lipids with superior delivery capacity.
Consequently, biochemists are interested in the pK values of the ionizable groups in proteins and how these pK values depend on their environment.
The ionizable groups of PG-1 were protonated or deprotonated assuming the pH for the unbound peptide and peptide in the membrane model to be equal to 7.0.
Similar results with substitutions of 6 randomly chosen internal positions in ribonuclease H with Lys and Glu suggest that the ability of proteins to tolerate internal ionizable groups might be a property common to many proteins.
Internal ionizable groups are quite rare in water-soluble globular proteins.