from The American Heritage® Dictionary of the English Language, 4th Edition
- n. Any of a group of organic compounds that facilitate the transport of ions across the cell membrane.
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. any substance that can transfer ions from a hydrophilic medium (such as water) to a hydrophobic medium, or across a biological membrane, normally by forming a complex with it; an ion carrier
from the GNU version of the Collaborative International Dictionary of English
- n. A compound that enhances transport of ions across cellular membranes, by binding them and carrying them across. As a class ionophores tend to be lipophilic in nature; each compound is usually specific for one or a small number of ions.
Sorry, no etymologies found.
The eggs were divided into two batches, one of which was fertilized, the other treated with calcium ionophore, A23187.
Bronner C, Landry Y The effect of cromoglycate and of natural flavonoids on histamine release from peritoneal rat mast cells induced by compound 48/80 and ionophore
In contrast, a short preincubation (2 min) of cells with quercetin or luteolin decreased their inhibitory effect on the ionophore-induced release, whereas a longer preincubation increased the inhibition.
Preincubation of cells with cromoglycate, dihydroquercetin and amentoflavone, a biflavonoid, decreased the potency of drugs to inhibit the ionophore-induced release; the optimal inhibitions were observed when drugs were added simultaneously with the ionophore A23187.
In fact, studies in animals and early, short-term clinical trials of zinc-ionophore drugs including clioquinol and PBT2 in people with Alzheimer's disease have so far produced promising results.
Third, we found that the calcium ionophore ionomycin caused ER fission but that, even in this case, ER fission required NMDA receptor activation.
Apart from glutamate, the calcium ionophore ionomycin was able to induce ER fission.
As control, we used a depolarized sample treated with ionophore Valynomicin for further 15 min after JC-1 staining.
When stimulated with progesterone or A23187 (a calcium ionophore), sperm from these animals had a defective acrosome reaction.
Acrosome reaction experiments indicate that the basic problem in sperm from hyh mice is a reduced capacity to undergo exocytosis upon stimulation with progesterone and even with a calcium ionophore.