isoprenylation love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The addition of a hydrophobic, isoprenoid group to a protein to facilitate attachment to cell membranes.

Etymologies

Sorry, no etymologies found.

Examples

  • A concentration of 10 ┬ÁM of GGTI-298 prevented protein isoprenylation and was only weakly toxic in our culture conditions (data not shown).

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  • Olson EN (2006) The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1.

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  • In particular, the inhibition of small guanosine triphosphate (GTP) - binding proteins Rho, Ras, and Rac, whose proper localisation and function in the membrane are dependent upon isoprenylation, plays an important role in signal transduction pathways that regulate cell proliferation, cell differentiation, vesicular transport and apoptosis

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  • REP-1 is involved in post-translational lipid modification (isoprenylation) of monomeric Rab GTPases (Rabs), which are key regulators of vesicular trafficking, phagosome fusion and maturation

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