Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry The addition of a
hydrophobic ,isoprenoid group to aprotein to facilitate attachment to cell membranes.
Etymologies
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Examples
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A concentration of 10 µM of GGTI-298 prevented protein isoprenylation and was only weakly toxic in our culture conditions (data not shown).
PLoS ONE Alerts: New Articles Guillaume Sarrabayrouse et al. 2010
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Olson EN (2006) The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1.
PLoS ONE Alerts: New Articles Priti Azad et al. 2009
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In particular, the inhibition of small guanosine triphosphate (GTP) - binding proteins Rho, Ras, and Rac, whose proper localisation and function in the membrane are dependent upon isoprenylation, plays an important role in signal transduction pathways that regulate cell proliferation, cell differentiation, vesicular transport and apoptosis
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In particular, the inhibition of small guanosine triphosphate (GTP) - binding proteins Rho, Ras, and Rac, whose proper localisation and function in the membrane are dependent upon isoprenylation, plays an important role in signal transduction pathways that regulate cell proliferation, cell differentiation, vesicular transport and apoptosis
PLoS ONE Alerts: New Articles Olof Grip et al. 2009
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REP-1 is involved in post-translational lipid modification (isoprenylation) of monomeric Rab GTPases (Rabs), which are key regulators of vesicular trafficking, phagosome fusion and maturation
PLoS ONE Alerts: New Articles Natalia V. Strunnikova et al. 2009
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