Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. Of or pertaining to kynurenic acid or its derivatives
from the GNU version of the Collaborative International Dictionary of English
- adj. Pertaining to, or designating, an acid obtained from the urine of dogs. By decomposition the acid yields a nitrogenous base (called kynurin) and carbonic acid.
from The Century Dictionary and Cyclopedia
- Same as cynnrenic.
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
Examples
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University of Maryland scientists have linked a brain compound called kynurenic acid to cognition, potentially opening the door to development of a drug that could aid learning in healthy people -- and in those with disorders such as Alzheimer's disease.
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Scientists develop new strategy that may improve cognition scientists have linked a brain compound called kynurenic acid to cognition, possibly opening doors for new ways to enhance memory function and treat catastrophic brain diseases, according to a new study from ...
WN.com - Articles related to Healthy Diet Could Slow Or Reverse Early Effects Of Alzheimer's Disease
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The finding suggests that drugs used to suppress the compound, called kynurenic acid, might be an important supplement to antipsychotic medicines, as these adjuncts could be used to treat the disorder's most resistant symptoms - cognitive impairments.
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Other problems and side effects could be triggered by a new drug to reduce kynurenic acid, once a chemical treatment is produced and tested in humans.
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They showed that serotonin is made in nerve cells in the brain, and kynurenic acid is made in glial cells.
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The odds are long for any new drug treatment gaining government approval for use in humans, but Schwarcz believes that the kynurenic acid discovery could be the breakthrough needed by pharmaceutical companies to produce a commercial product.
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Schwarcz and other scientists have been studying the link for more than a decade and can now show that mice genetically engineered to produce 70 percent less kynurenic acid had markedly improved cognition.
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Scientists have long known of the existence of kynurenic acid and glial cells, but until this discovery, scientists thought the primary role of such cells was to provide support and protection for the nerve cells.
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Conversely, abnormally high levels of kynurenic acid are found in people with brain disorders such as schizophrenia, Alzheimer's and Huntington's, which may contribute to cognitive problems.
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Coronal slices were obtained by cutting with a Leica vibratome VT1000S in the presence of the ionotropic glutamate receptor inhibitor kynurenic acid (2 mM).
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