Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A humanized monoclonal antibody for the treatment of colorectal cancer.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

-tu- +‎ -zu- +‎ -mab

Examples

  • In a mouse model of human pancreatic cancer, SN-38 conjugates of labetuzumab and hRS7 produced enhanced antitumor effects versus veltuzumab-SN-38 conjugate, which does not target pancreatic cancer, suggesting the binding abilities of labetuzumab and hRS7 were retained in both conjugates.

    The Earth Times Online Newspaper

  • The first study reported at the AACR conference evaluated 4 linkers to connect SN-38 to labetuzumab or hRS7, two of the Company's proprietary humanized monoclonal antibodies.

    The Earth Times Online Newspaper

  • (Nasdaq: IMMU), a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, announced that results presented at the 2009 Gastrointestinal Cancers Symposium showed that labetuzumab-SN-38, an antibody-drug conjugate, selectively delivers SN-38 to human colon carcinoma in animal models as an effective new therapy.

    Health News from Medical News Today

  • In this study, the therapeutic efficacy of SN-38 conjugated to labetuzumab was evaluated in two animal models of human colon cancer.

    Health News from Medical News Today

  • "We believe these results suggest that targeted chemotherapy of colorectal cancer with labetuzumab-SN-38 should enhance the bioavailability and reduce the toxicity of the clinically validated drug, irinotecan," commented Cynthia L. Sullivan, President and CEO.

    Health News from Medical News Today

  • In a lung metastatic model of colon carcinoma, therapy with labetuzumab-SN-38 conjugate increased median survival time (MST) 1.9 - to 3. 4-fold compared to various controls, with 20\% of animals alive at the end of the study.

    Health News from Medical News Today

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