lactacystin

Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.

Not all "Lact" Words Are the Same Steve Carper 2008

The cleavage of GAD67 was sensitive to the proteasome inhibitors MG132, YU102 and lactacystin, and was also abrogated by the E1 ubiquitin ligase inhibitor UBEI-41.

Elites TV PLoS ONE 2010

Therefore, three proteasomal inhibitors, MG132, clasto-lactacystin β-lactone and epoxomicin, were tested for their ability to suppress the ENC1-induced decrease in Nrf2 expression.

PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009

Yew EH, Cheung NS, Choy MS, Qi RZ, Lee AY, et al. (2005) Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.

PLoS ONE Alerts: New Articles 2009

The aim of this project is to establish a rapid and efficient total synthesis of the proteolytic enzyme inhibitors lactacystin, PS-519, the core structure of

Naturejobs - All Jobs 2009

Transfected cells were treated with proteasome inhibitors MG132 (M) (10 µM), clasto-lactacystin β-lactone (Lac) (10 µM) or epoxomicin (Ep) (1 µM), or lysosome inhibitors chloroquine (Ch) (50 µM) or ammonium chloride (Ac) (50 mM) for 4 hr before cells were lysed at

PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009

Similar levels of induction were observed when clasto-lactacystin β-lactone or epoxomicin was used (

PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009