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- n. A selective proteosome inhibitor found in Streptomyces bacteria.
Sorry, no etymologies found.
Here's the question: Just found out that lactacystin is an inhibitor of proteosome activity and may therefore be related to experimentally induced Alzheimers.
The cleavage of GAD67 was sensitive to the proteasome inhibitors MG132, YU102 and lactacystin, and was also abrogated by the E1 ubiquitin ligase inhibitor UBEI-41.
Therefore, three proteasomal inhibitors, MG132, clasto-lactacystin β-lactone and epoxomicin, were tested for their ability to suppress the ENC1-induced decrease in Nrf2 expression.
Yew EH, Cheung NS, Choy MS, Qi RZ, Lee AY, et al. (2005) Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.
The aim of this project is to establish a rapid and efficient total synthesis of the proteolytic enzyme inhibitors lactacystin, PS-519, the core structure of
Transfected cells were treated with proteasome inhibitors MG132 (M) (10 µM), clasto-lactacystin β-lactone (Lac) (10 µM) or epoxomicin (Ep) (1 µM), or lysosome inhibitors chloroquine (Ch) (50 µM) or ammonium chloride (Ac) (50 mM) for 4 hr before cells were lysed at
Similar levels of induction were observed when clasto-lactacystin β-lactone or epoxomicin was used (