lamellipodial

Activation of PI3-kinase leads to up-regulation of Rac1, followed by the activation of JNK, resulting in formation of lamellipodial extension.

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

Therefore, our data suggest that bFGF induced lamellipodial extension of the fibroblasts and promoted migration.

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

This lamellipodial extension provides the driving force for the protrusive activity required for cell migration

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

** P doi: 10.1371/journal. pone.0012228.g001 bFGF promoted fibroblast migration and induced lamellipodial extension

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

In our study, the bFGF-treated fibroblasts showed more lamellipodial extension at 1 h after wounding as compared to the control cells.

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

Rac1 induces the formation of lamellipodial protrusions via activation of the Wave complex

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

Fig. 2C, the bFGF-treated fibroblasts significantly developed lamellipodial extension in the scratch wound.

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

The bFGF-treated fibroblasts developed lamellipodial extension (arrowhead).

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

Lamellipodial extension was quantified by summing the length of the outer margins of all lamellipodium in individual cells, and was expressed as a proportion of the total perimeter of each cell (lamellipodial index), as described by Verma et al. [24]. bFGF induced lamellipodial extension at 1 h

PLoS ONE Alerts: New Articles Shigeyuki Kanazawa et al. 2010

Hu H, Kim YH, Beggs HE, Reichardt LF, et al. (2006) Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

PLoS ONE Alerts: New Articles Ruchika Srinivasan et al. 2009