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- n. A drug used in combination with niacin to reduce blood cholesterol.
Sorry, no etymologies found.
In April, it tried to launch a new cholesterol drug, Cordaptive, that combines niacin, a B vitamin which raises HDL but causes facial flushing with laropiprant, an anti-flushing drug, without waiting for study results, like it did with Vytorin.
Not only did the company want to start marketing before safety studies were completed and while admitting "theoretical" safety concerns about the drug's effect on liver according to the The Star-Ledger, this week Merck abruptly halted a 900 patient laropiprant study altogether and many are asking why.
The Merck compound combines niacin with a new chemical entity, laropiprant, designed to minimize the skin-related side effect.
To make Cordaptive, Merck adds a new agent, laropiprant, to turn down the flushing.
(HPS2-THRIVE), which has enrolled 25,000 patients to investigate whether the combination of niacin/laropiprant can further reduce the risk for myocardial infarction, stroke and the need for revascularisation in patients already treated to lower LDL.
It is hoped that laropiprant, a novel flushing pathway inhibitor, will overcome this limitation.