Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A selective estrogen receptor modulator used in treating
osteoporosis ,breast cancer , andvaginal atrophy .
Etymologies
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Examples
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By Julie Steenhuysen Pfizer's experimental osteoporosis drug lasofoxifene, which is awaiting US regulatory approval, works about as well as currently approved drugs, but not much
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(LGND) for osteoporosis compounds -- lasofoxifene (with Pfizer) and basedoxifene (with Wyeth).
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The FDA recently rejected pharmaceutical company Pfizer's request for approval, meaning that while it is approved and available in Europe, it is not available here in the U.S. Dr. Cummings and several of the other researchers involved in this study received consulting grants from Pfizer, the manufacturer of lasofoxifene.
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At the end of the five years patients who took lasofoxifene experienced fewer vertebral fractures than the placebo group a 58 percent reduction in the patients taking 0. 5mg a day and
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Endometrial cancer occurred in three women in the placebo group, two women in the lower-dose lasofoxifene group, and two women in the higher-dose lasofoxifene group.
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Low doses of the medication lasofoxifene can reduce the risk of vertebral and non-vertebral osteoporosis.
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Those taking lasofoxifene also experienced increases in bone density compared to the placebo group.
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Patients taking lasofoxifene were at higher risk of experiencing a venous thromboembolic event or blood clot.
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Patients taking lasofoxifene experienced a reduction in their risk of estrogen receptor (ER) positive breast cancer (81 percent and 48 percent respectively), and a reduction in LDL (the so-called bad) cholesterol of around 16 percent.
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Two thirds of the women were given a daily dose of lasofoxifene (either 0. 25mg or 0. 5mg) and the other third were given a placebo.
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