Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
inhibitor ofpyrimidine synthesis , used to treat some forms ofarthritis .
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun an anti-TNF compound (trade name Arava) that is given orally; can slow the progression of rheumatoid arthritis by slowing the proliferation of white blood cells which reduces inflammation in the synovium
Etymologies
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Examples
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The effect was even more powerful when leflunomide was combined with an experimental melanoma drug called PLX4720.
WalesOnline - Home 2011
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Tests showed that the drug, leflunomide, significantly reduced tumour growth in mice with human-like melanoma.
WalesOnline - Home 2011
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The stage is now set for clinical trials to investigate the effect of leflunomide on melanoma patients.
WalesOnline - Home 2011
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The manufacturer of leflunomide, sanofi-aventis, also encouraged referrals.
MedPageToday.com - medical news plus CME for physicians 2010
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In addition, the study enrolled fewer than the target number of patients designed to detect a 10% difference in outcome, but the investigators pointed out that during the long enrollment period, other drugs were introduced that frequently replaced leflunomide.
MedPageToday.com - medical news plus CME for physicians 2010
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Women with rheumatoid arthritis who inadvertently became pregnant while taking leflunomide
MedPageToday.com - medical news plus CME for physicians 2010
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The OTIS investigators also followed a group of 19 infants born to exposed mothers who were not eligible for the cohort study for reasons such as use of leflunomide for other conditions and found two major structural defects.
MedPageToday.com - medical news plus CME for physicians 2010
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The agency previously required a Boxed Warning stating that leflunomide was contraindicated in pregnant women, or women of childbearing potential who were not using reliable contraception.
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Explain to interested patients that if they became pregnant while taking leflunomide, their offspring are unlikely to have major malformations, even though the drug is category X.
MedPageToday.com - medical news plus CME for physicians 2010
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"Therefore, this study is not able to address possible risks associated with use of leflunomide over the entire period of embryonic development," the investigators said.
MedPageToday.com - medical news plus CME for physicians 2010
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