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Examples
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High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types.
BioMed Central - Latest articles Jon Briggs 2010
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These results suggest that the level of cystatin E/M regulates legumain activity and hence the invasive potential of human melanoma cells.
BioMed Central - Latest articles Jon Briggs 2010
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When melanoma cells lacking secretion of cystatin E/M were transfected with pCST6, their intracellular legumain activity was significantly inhibited.
BioMed Central - Latest articles Jon Briggs 2010
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Hajdusek O, Dvorak J, Sajid M, Franta Z, et al. (2007) IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
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