levocetirizine love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A third-generation nonsedative antihistamine.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

levo- +‎ cetirizine

Examples

  • Rx Pharmaceuticals: The company reported Rx Pharmaceuticals revenue of $97.5 million in second quarter of fiscal 2011, up 72% over the prior year driven by increased sales volume and higher sales of new products like Imiquimod cream generic version of Aldara and levocetirizine tablets, a generic version of Xyzal, for allergies.

  • Xyzal® (levocetirizine dihydrochloride) is indicated for the relief of symptoms associated with perennial allergic rhinitis and the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older, and for relief of symptoms of seasonal allergic rhinitis in adults and children 2 years of age and older.

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  • The use of Xyzal® is contraindicated in: patients with a known hypersensitivity to levocetirizine or any of the ingredients of Xyzal®or to cetirizine (observed reactions range from urticaria to anaphylaxis); patients with end-stage renal disease with a creatinine clearance less than 10 mL/min or patients undergoing hemodialysis; and pediatric patients aged

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  • Xyzal® (levocetirizine dihydrochloride) in the U.S.

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  • April 2008, Vol. 9, No. 5, Pages 859-867 "Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig."

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  • "Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine."

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  • Antihistamine Pharmacology Levocetirizine vs Cetirizine - Studies show significant improvement in subjective rating of symptoms following a course of Levocetirizine or Cetirizine compared to placebo - One 12 week program demonstrated statistically significant superiority in relieving symptoms using cetirizine in 6-12 year old population* "The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis" Pediatr Allergy Immunol.

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  • Antihistamine Pharmacology Levocetirizine: Beyond H1 Antagonism - Reduces expression of IL-6, IL-8, and GM-CSF - Reduces percentage representation of cell phenotypes known to contribute to inflammatory tissue damage (eosinophils, CD4+CD29+, CD4+CD212+, and CD4+CD54+) and expands percentages of CD4+CD25+ - Inhibits production of rhinovirus-induced ICAM-1 and NF-kappaB expression "Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells."

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  • Antihistamine Pharmacology "Heritage" - Following administration of hydroxyzine, a 1st generation antihistamine, the major metabolite in the blood is cetirizine - Cetirizine is a racemic mixture of dextrocetirizine and levocetirizine

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  • Antihistamine Pharmacology Levocetirizine - While both cetirizine and hydroxyzine possess high affinity at the H1 receptor, the R - configured levocetirizine has much slower dissociation rate from the H1 receptor than R - hydroxyzine, making it an insurmountable antagonist.

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