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Only two of 13 patients given the top virus treatment dose relapsed, and no patient had recurrent loco-regional disease.
The use of magnetic resonance imaging (MRI) prior to breast-conserving surgery does not improve loco-regional staging compared with conventional staging methods among women with early breast cancer.
Combinations of chemotherapy and radiotherapy are also improving outcomes of loco-regional non-small-cell lung cancer.
Hence, loco-regional cytokines delivery or targeted therapy based on antibodies or molecules directed to the tumor stroma might improve anti-tumor immunity and ameliorate fibrosis, without systemic toxicity.
Treatment options for loco-regional recurrent breast cancer after previous irradiation are limited.
The authors note the heterogeneity of they loco-regional therapy may be a weakness of their study, and that the optimal treatment should be determined on a case-by-case basis.